iPSC Differentiation

Discovery of induced pluripotent stem cell (iPSC) reprogramming and differentiation offers unprecedented opportunities in disease modeling and drug discovery in stem cell research. Elixirgen Scientific can help accelerate your research using our proprietary technology to provide fast and reliable differentiation of induced pluripotent stem cells (iPSC) for limitless applications. Human iPSCs revolutionize the study of human biology and your lab can access the power with our services. Using our iPSC services enables researchers to harness the benefits of the latest biomedical research tools.

Benefits with Quick-Tissue Technology

At the heart of our services lies the Quick-Tissue technology. This proprietary technique enables efficient and reliable differentiation of iPSCs into various cell types. Our custom iPSC differentiation service employs this technology, allowing researchers to have easy access to high-quality differentiated cells for their experiments by our internal iPSC experts. These differentiated cells can be used in a multitude of applications, including disease modeling, biomarker detection, and drug testing.


  • Rapid differentiation
  • Functionally validated
  • Reproducible
  • Scaleable

How Our Differentiation Service Works



Project Design Consultation

Whether you’re an experienced iPSC researcher or just getting started, our scientists are here to answer your questions and provide ongoing support. All iPSC services begin with a free consultation to define the scope of the project, including the desired differentiated cell type, the production scale (1-50 million viable cells), and desired characterization assays (ICC, MEA, etc.).

If you don’t currently have an iPSC line, we can also provide assistance in obtaining iPSC lines from iPSC banks or gene-editing service providers. Consultations are free, so request a consultation today to discuss your project requirements. iPSC lines Elixirgen recognize are listed here.



iPSC Expansion or Adaptation (Optional)

Upon receiving your frozen or live iPSC line(s), we expand or adapt the cells in optimal conditions for growth and differentiation. For our transcription factor-based differentiation platform, we use feeder-free, single-cell passaging conditions for iPSC expansion/adaptation for best results.

During iPSC expansion, we can produce working and back-up stocks of the iPSC line along with a certificate of analysis to verify pluripotency, karyotype, and any kind of iPSC assay upon request.



iPSC Differentiation

Our proprietary iPSC differentiation technology produces functional, highly pure populations neurons in as little as 1 week without leaving a genetic footprint.

Our standard differentiated cell types include a variety of neuronal subtypes (excitatory, GABAergic, dopaminergic, cholinergic, or sensory) and astrocytes but we can also use our iPSC expertise to develop a custom differentiation strategy for generating your desired cell or tissue type.




Prior to shipment or additionally requested assays, we conduct a variety of quality control checks to ensure that differentiated cells are free from contaminants, express lineage-specific markers, and have optimal post-thaw viability.

We also offer a variety of optional in-house assay services, including microelectrode array (MEA), neurite outgrowth assay, and calcium transient assay, if in depth functional characterization is desired.

Cryopreserved differentiated cells or their derivatives such as RNA and supernatant are shipped  depending on preference. Cryopreserved differentiated cells are supplied with media supplements and detailed instructions for optimal cell maintenance.

Questions? Comments? Ask Us

Frequently Asked Questions

How much do the iPSC services cost?

The price for the differentiation of one hPSC (iPS or ES) line varies based on multiple factors and requirements such as iPSC expansion requirement, number of cells required, QC criteria etc. Contact us to share your requirements and start discussion.

I don't have my own cells, where can I order an iPSC line?

If you do not already have an established iPSC line, you can find patient iPSC lines in your interest here. Contact us for you to learn more about sourcing iPSC lines and differentiation.

How do I ship my hPSC line?

Sending biomaterials is always challenging. However, Elixirgen Scientific has a lot of experience in cross border logistics for cells and biological materials. Our knowledge and expertise will navigate you to properly prepare your iPSCs to ship. We use dry ice shipment in the US and liquid nitrogen dry shipper internationally to ship cryopreserved cells. We can also accept live hPSC lines to speed up an entire process and lower total fees.

Can you reprogram my cells into iPSCs?

We do not currently offer services for reprogramming cells into iPSCs. However, we can work with our partners to take care of this reprogramming services from fibroblast or PBMC.


List of diseases and mutations.

Transform how you study disease with Quick-Tissue™ technology
With Quick-Tissue™ technology, you can study disease state from multiple angles in vitro. Thanks to advance in iPSC reprogramming technology, there are thousands of iPSC lines available for your disease study. Look through the iPSC line database below to find out your diseases in interest exist. The database also lists identified mutant genes. Feel free to reach us to how we can help getting differentiated cells derived from iPSC lines in your interest.

DiseaseMutant genes (# of iPSC lines)Number of total patient iPSC lines
ABCA1 heterozygousABC1 (2)2
AbetalipoproteinemiaMTP (2)2
Acromesomelic dysplasiaNPR2 (1)1
Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD)1
Adrenoleukodystrophy (ALD)1
Adult-onset Still’s disease (AOSD)1
Age-related macular degeneration (AMD)121
Aicardi syndrome1
Alexander diseaseGFAP (3)6
Allergic granulomatous angiitis1
Alzheimer's disease (AD)APOE (10), APOE4 (3), APP (4), C9ORF (1), CD33 (2), MAPT (2), PSEN1 (14), PSEN2 (1), TBK1 (1), TREM2 (3)180 (Available Differentiated cells)
Alzheimer's disease (AD) (Gene-edited)APP (6), PSEN1 (8)14
Alzheimer's disease (AD) (familial)APP (3), APPV7171 (4), PSEN1 (1), PSEN2 (1)11
Amyotrophic lateral sclerosis (ALS)ASYMPTOMATIC C9ORF72 CARRIER (1), C9ORF72 (46), FIG4 (1), FUS (3), SETX (1), SETX, SOD1 (1), SOD1 (36), SOD1 > D90A (1), TARDBP (5), VCP (1)532
Anemia (phenotype)1
Angelman syndromeUBE3A (2)10
Aplastic anemia3
Arrhythmogenic right ventricular cardiomyopathy2
Associated pulmonary arterial hypertension18
Atrial fibrillation14
Atrial tachycardia1
Autism spectrum disorder (ASD)110 (Available Differentiated cells)
Autoimmune hemolytic anemia (AHA) / Idiopathic warm (AHA)1
Bardet-biedl syndrome22
Batten disease (cln3)CLN3 (23)23
Batten disease (cln6)8
Behçet’s disease2
Beta thalassemiaHBB (2)2
Bethlem myopathy2
Bilateral frontoparietal polymicrogyriaGPR56 (1)1
Bipolar disorder30
Blinding eye disease18
Borderline NASH (fatty liver disease)2
Breast cancerBRCA1 (3)3
Brugada syndrome6
Buerger’s disease1
Carpal tunnel syndrome18
Catecholaminergic polymorphic ventricular tachycardiaRYR2 (2)2
Ccanavan DiseaseASPA (1)1
Cchoroideremia (CHM)CHM (1), NGLY1 (1)4
Cerebral creatine deficiency syndrome 1 (CCDS1)SLC6A8 (1)1
Cerebral palsy (CP)19
Cerebrovascular disease4
Ceroid lipofuscinosisCHM (1), CLN2 (1)2
Charcot-Marie-Tooth diseaseFIG4 (1), MFN2 (10), MPZ (2), PMP22 (7), VCP (1)22
Chromosome 16p11.2 deletion syndrome5
Chronic inflammatory demyelinating polyneuropathy (CIDP)2
Chronic myeloid leukemia1
Congenital disorder of deglycosylation (CDDG)CFTR (1)1
Congenital heart block2
Congenital ichthyosis / Ichthyosis syndrome1
Congenital insensitivity to pain with anhidrosis (CIPA)2
Congenital myasthenic syndromeGFPT1 (1)7
Congenital myopathyMTM11 (1)1
ControlC9ORF72 (5), CCR5 (1), GFAP CORRECTED (2), HBB (1), HD (5), HNF1A (1), MECP2 (2), NGN2 (2), SNCA (1), SOD1 > D90A CORRECTED (1), TAF1 VARIANT CORRECTED (4)25
Coronary artery disease43
Corticobasal degeneration (CBD)1
Crohn's disease3
Crow‐Fukase syndrome2
Cystic Fibrosis (CF)DMPK (1)1
DMRV / GNE myopathy2
Danon disease1
Definite NASH (fatty liver disease)32
DiabetesHNF1A (2)3
Diabetes mellitus60
Diabetes mellitus type II12
Diabetes type I21
Diabetes type II95
Diabetes type unknown4
Diabetic retinopathy (DR)32
Diamond-Blackfan anemia1
Dilated cardiomyopathy (DCM)303
Distal Myopathy3
Down syndrome47,XX,+21 (4), 47,XY,+21 (3)8
Dravet syndromeSCN1A (11)11
Drug-induced liver injury (DILI)4
Duchenne Muscular dystrophy (DMD)DMD (1)2
Dystrophia myotonica 1 (DM1)DMPK (1)1
Ehlers-Danlos syndromeCOL3A1 (1)2
Eosinophilic granulomatosis with polyangiitis (EGPA)1
Eosinophilic sinusitis1
Epidermolysis bullosa1
EpilepsyALG13 (1), GABRA1 (1), KCNC1 (1), PCDH19 (2), SCN2A (1)57 (Available Differentiated cells)
Fabry disease3
Facioscapulohumeral muscular dystrophy 1 (FSHD1)LRIF1 (1)6
Familial Mediterranean fever1
Fatty liver disease - steatosis (not NASH)2
Focal cortical dysplasia (FCD)2
Focal segmental glomerulosclerosis20
Fragile X syndromeFMR1 (4)4
Friedreich ataxia 1 (FRDA)FXN (2)2
Frontotemporal degenerationC9ORF72 (4), GRN (4), MAPT (10), PGRN (2), VCP (1)25
Frontotemporal dementia (FTD)C9ORF72 (6), MAPT (15)30
Frontotemporal lobar degeneration (FTLD)2
Gaucher diseaseGBA (1)2
Giant cell arteritis (GCA)2
Glut1 deficiency syndrome 1 (Glut1DS1)SLC2A1 (1)1
Glycogen storage disease / GSD type V (muscle glycogen phosphorylase deficiency)1
Glycosylphosphatidylinositol(GPI) anchor deficiency3
Granulomatosis with polyangiitis (GPA)1
Hemiconvulsion-hemiplegia-epilepsy syndrome2
Hepatitis C (HCV)91
Hereditary dystonia1
Homozygous familial hypercholesterolemiaLDLR (6)6
Hunter syndrome2
Huntington's disease (HD)HD (14), HTT (36), IT15 (1), SMN1 (1)58
Hurler syndromeIDUA (1)1
Hutchinson-gilford progeria syndrome (HGPS)2
HyperalphalipoproteinemiaSR-BI (2)2
Hypertrophic cardiomyopathyTNNT2 (1)83
Idiopathic aplastic anemia1
Idiopathic pulmonary arterial hypertension16
Idiopathic pulmonary fibrosis (IPF)182
Idiopathic thrombocytopenic purpura1
IgG4-related disease1
IgG4-related thyroid disease1
Inappropriate sinus tachycardia1
Infantile neuroaxonal dystrophy (INAD)PLA2G6 (5)5
Intellectual disability (ID)60
Interstitial lung disease1
Isaacs syndrome1
Isogenic control3
Kearns-sayre syndrome (KSS)1
Krabbe diseaseGALC (1)1
Landau-Kleffner syndrome1
Left ventricular hypertrophy15
Left ventricular non-compaction cardiomyopathy10
Lennox-Gastaut syndrome (LGS)2
Lesch-nyhan syndrome (LNS)HPRT1 (1)1
Lewy body dementia8
Lewy body dementia (LBD)1
Limb-girdle muscular dystrophyDYSF (5)5
Limb-girdle muscular dystrophy (LGMD2b)DYSF (15)15
LissencephalyDCX (1)1
Long QT syndrome3
Long QT syndrome (familial)13
Long QT syndrome 1 (LQT1)3
Long QT syndrome 2 (LQT2)KCNH2 (1)1
Long QT syndrome 3 (LQT3)SCN5A (1)1
Malignant rheumatoid arthritis (MRA)1
Mental illnessDISC1 EXON 8 WILD-TYPE (2)2
Mental retardationCHAMP1 (2), SYNGAP1 (1)3
Mesial temporal lobe epilepsy with hippocampal sclerosis2
Microscopic polyangiitis (MPA)1
Mild left ventricular hypertrophy1
Miller-dieker lissencephaly syndrome (MDLS)1
Mitochondrial diseases1
Mixed Connective-Tissue Disease (MCTD)1
Monogenic diabetes13
Mortor dominant1
Moyamoya disease3
Mucopolysaccharidosis (MPS)SGSH (1)3
Multifocal motor neuropathy (MMN)1
Multiple sclerosis (MS)4
Multiple system atrophy (MSA)6
Muro disease (Kii ALS/PDC)3
Muscular dystrophyDMD (5), LAMA2 (1), POMT2 (1)9
Myasthenia Gravis (MG)1
Myocardial infarction18
Myoclonic epilepsyCHD2 (1)1
Myotonic dystrophyCNBP (4), DMPK (1)9
Nescav syndromeKIF1A (5)6
Neurodegeneration with brain iron accumulation 5 (NBIA5)WDR45 (1)1
Neurodevelopmental disorderDHPS (1)1
Neurofibromatosis type1 (NF1)1
Neurofibromatosis type2 (NF2)1
Neuromyelitis Optica4
Neuromyelitis Optica Spectrum Disorders (NMOSD)1
Neuronal migration disorderPIK3R2 (1)3
NeuropathyGARS (2), SCN9A (6)39
Niemann-pick diseaseNPC1 (1), SMPD1 (3)5
Non-als motor neurone disease1
Ohtahara syndromeSTXBP1 (1)1
Ornithine transcarbamylase deficiency (OTCD)1
Osteogenesis imperfecta type iv (OI4)COL1A2 (1)1
PACS1 (Schuurs-Hoeijmakers) syndromePACS1 (2)2
Pain agnosiaSCN11A (2)2
ParkinsonismGBA (2), LRRK2 (6), MAPT (1), PARK2 (4), PINK1 (1), SNCA (3)26
Parkinson’s disease (PD)GBA (18), LRRK2 (8), SNCA (9)99
Paroxysmal nocturnal hemoglobinuria (PNH)1
Pemphigoid (including epidermolysis bullosa acquisita)2
Periodic paralysis1
PhenylketonuriaPAH PAH (1)2
Pick's disease1
Pitt-hopkins syndrome (PTHS)TCF4 (1)1
Polyarteritis nodosa (PAN)2
Pompe’s disease (adult type)1
Primary antiphospholipid syndrome2
Primary erythromelalgiaSCN9A (2)4
Primary immunodeficiency syndrome3
Primary lateral sclerosis (PLS)7
Primary open angle (POAG)20
Primary progressive aphasia (PPA)1
Progressive multifocal leukoencephalopathy (PML)1
Progressive supranuclea palsy (PSP)1
Prolonged QT interval6
Pulmonary arterial hypertension ALK1 (2), BMPR2 (4)6
Pulmonary atresia1
Pustular psoriasis1
Pyogenic sterile arthritis / Pyoderma gangrenosum and acne syndrome1
Rasmussen encephalitis2
Relapsing polychondritis (RP)1
Resolved systolic anterior motion1
Restrictive cardiomyopathy1
Retinitis pigmentosa5
Rett syndromeFOXG1 (5), MECP2 (6), SHANK3 (1)15
Right ventricular outflow tract premature ventricular contractions2
Ring chromosome 20 syndrome2
Sanfilippo syndrome / MPS IIIC (acetyl-CoA:heparan-α-D-glucosaminide N-acetyltransferase deficiency)1
Semantic Dementia2
Severe combined immunodeficiencyADA (2)2
Sickle cell anemiaHBB (55)55
Sjögren’s syndrome1
Skeletal displasia4
Small atrial septal defect1
Smith-magenis syndrome (SMS)1
Spinal muscular atrophySMN1 (14)18
Spinal-Bulbar Muscular Atrophy (SBMA)10
Spinocerebellar Degeneration14
Spinocerebellar ataxia type 12
Spinocerebellar ataxia type 3ATXN3 (4)4
Spondylometaphyseal displasia2
Stevens-Johnson syndrome (SJS)1
Sturge-Weber syndrome1
Subacute sclerosing panencephalitis (SSPE)2
Systemic amyloidosis2
TNF receptor-associated periodic syndrome1
Takayasu arteritis3
Tangier diseaseABC1 (2), ABCA1 (4)6
Tay-sachs disease (TSD)HEXA (1)1
Thrombotic thrombocytopenic purpura (TTP)1
Tricuspid atresia1
Tuberous sclerosisTSC2 (2)3
Ventricular tachycardia5
Vertebrobasilar insufficiency(VBI)1
Vici syndrome (VICIS)EPG5 (1)1
Werner syndrome1
West syndrome1
Wilson’s disease4
Wolfram syndrome1
Wolman disease1
X-linked creatine transporter deficiency1
X-linked dystonia ParkinsonismTAF1 VARIANT (34)34
Xeroderma pigmentosum2