Alzheimer's Disease Panel
Alzheimer’s Disease Patient-Derived human iPSC Neuron Panel
Our Alzheimer’s Disease (AD) panel provides the most advanced and robust cell-based model for predictive testing of AD drug candidates.
- Immediate Access to Comprehensive Patient Data
The AD panel provides immediate access to patient-derived neurons that have undergone complete molecular profiling, offering essential endpoints. Several astrocyte and microglia lines are also available for tri-culture and organoid work.
- Quick Start to Therapeutic Discovery
The AD panel is assay ready, enabling researchers to jump-start their experiments without the need for extensive assay optimization. Patient-derived iPSCs carry the genetic risk factors of the patients, offering insights into how genetics influences sporadic AD. This may accelerate the identification of biomarkers for patient stratification, as well as personalized drug screening and testing.
- Fully Customizable for Any Assay Readout
The AD panel is fully customizable, supporting a wide range of assay readouts. This allows for a versatile and tailored approach to AD drug development.
Visualize Alzheimer's Disease Pathways
Our AD Panel includes high-resolution immunofluorescence image data, providing details into cellular morphology and marker expression. This powerful visualization tool aids in the precise identification and analysis of key biomarkers associated with AD pathology.
Human iPSC-derived excitatory neurons express neuronal markers and display typical neurite growth. Immunofluorescent staining of Quick-Neuron™ Excitatory - hiPSC-derived Neurons at week 4 post-thaw show expression of the pan-neuronal marker TUBB3 (green) and the glutamatergic neuron marker vGLUT1 (red). Bars = 100 µm
Quantify with Precision
Gain accurate and reliable quantitative data with our endpoint ELISA assays. Our AD Panel offers robust and reproducible ELISA data, enabling researchers to measure protein levels and detect changes in established biomarkers critical for AD research.
Amyloid ꞵ42, pTau, and Tau levels normalized per 1000 neurons assayed on week 6 post-differentiation in 7 AD patient-derived hiPSC excitatory neurons. Amyloid ꞵ42 was assayed in cell supernatants and Tau and pTau were measured in lysates by ELISA. Cell numbers were quantified with Hoechst by ICC. ApoE genotype is indicated for each hiPSC line: black bars are for ApoE3/4 and blue bars are for ApoE4/4 .
Explore Neurons and Glial Cells from Patient-Derived hiPSCs
These well-characterized hiPSC lines provide a valuable resource for studying disease mechanisms, testing potential therapies, and advancing personalized medicine approaches in AD research. Discover the genetic diversity and detailed profiles of our patient-derived hiPSC lines to enhance your scientific investigations.
| Line ID | APOE status | Sex | Race | Sampling age | Age at Onset | Height (inches) | Weight (pounds) | Source | EX Neuron |
|---|---|---|---|---|---|---|---|---|---|
| CW13000 | 2/2 | F | Caucasian | 81 | N/A (Healthy) | N/A | N/A | PBMC | Ready |
| CW13030 | 4/4 | F | Japanese | 62 | 56 | 58.5 | 106 | PBMC | Ready |
| CW13032 | 4/4 | F | Caucasian | 87 | 74 | 60.2 | 126 | PBMC | Ready |
| CW13037 | 3/3 | F | Caucasian | 89 | N/A (Healthy) | N/A | N/A | PBMC | Ready |
| CW13049 | 3/3 | F | Caucasian | 69 | 63 | 50.3 | 169 | PBMC | Ready |
| CW13074 | 4/4 | F | Caucasian | 71 | 66 | 63 | 110 | PBMC | Ready |
| CW13098 | 4/4 | F | Caucasian | 88 | 79 | 55.5 | 116 | PBMC | In Process |
| CW50023 | 3/4 | M | Caucasian | 69 | N/A | N/A | N/A | PBMC | Ready |
| CW50025 | 3/4 | F | Caucasian | 68 | 57 | 63 | 118 | PBMC | In Process |
| CW50033 | 2/3 | M | Caucasian | 75 | N/A (Healthy) | N/A | N/A | PBMC | Ready |
| CW50065 | 2/4 | F | Caucasian | 74 | N/A (Healthy) | N/A | N/A | PBMC | Ready |
| CW50104 | 4/4 | M | Caucasian | 79 | 73 | 68 | 160 | PBMC | In Process |
| CW50107 | 3/4 | M | Caucasian | 72 | 65 | 71 | 202 | PBMC | Ready |
| CW50113 | 3/4 | M | Caucasian | 68 | 52 | 68 | 242 | PBMC | Ready |
| CW50114 | 3/4 | F | Caucasian | 72 | 65 | 63 | 130 | PBMC | Ready |
| CW50115 | 3/4 | F | Caucasian | 67 | 58 | 59 | 136 | PBMC | In Process |
| CW50137 | 4/4 | F | Caucasian | 70 | 62 | 66 | 122 | PBMC | Ready |
| CW50147 | 3/4 | M | Caucasian | 71 | 62 | 69 | 175 | PBMC | Ready |
| CW50150 | 3/3 | F | Caucasian | 65 | N/A (Healthy) | N/A | N/A | PBMC | Ready |
| CW50169 | 4/4 | F | Caucasian | 68 | Unknown | 65 | 145 | PBMC | Ready |
| CW50174 | 3/4 | F | Caucasian | 76 | Unknown | 64 | 133 | PBMC | Ready |
| CW50176 | 3/4 | M | Caucasian | 74 | Unknown | 69 | 164 | PBMC | Ready |
Comprehensive Solutions for Alzheimer's Disease Research
Elixirgen Scientific's AD Panel delivers a complete suite of tools designed to support your research endeavors. Explore our offerings and see how we can enhance your AD research today.
