Services

Get your studies off the ground fast with Elixirgen Scientific’s stem cell services including high content imaging, electrophysiological assay, transcriptome analysis, RT-qPCR, and drug screening. Our proprietary technology enables stem cell differentiation with a faster turnaround time than any other preclinical service provider in the world. Let's discuss your projects with us.

Service deliverable examples

ALS Disease Study
Healthy control and ALS patient-derived iPSCs were differentiated into cholinergic neurons. The cells were fixed at day 10 from iPSCs and stained by TUBB3 (Green) and TDP-43 (Red).

MEA (multi-electrode array) assay

Your drug candidates could be tested on MEA plate after iPSC differentiation. Healthy control and disease patient iPSC line derived cells could be plated onto the same MEA plate to test quantitative property changes with drug candidates.

Neurite length analysis

Our fast differentiation enables quicker and quantitative comparison between healthy and patient or treated and non-treated cultures.

Global transcriptome analysis

Our bioinformatic team enables unbiased analyses with transcriptome datasets from RNA-sequence and microarray. If you would like to capture global difference between patient and healthy/isogenic control or non-treated or treated cultures, let's discuss with us for designing experiments.

Antibody validation
Antibody used for fluorescent imaging always with questions for specificity. Elixirgen Scientific can use iPSCs and mRNA transfection to generate a proper positive controls to identify its specificity.

New differentiation protocol development

Elixirgen Scientific proprietary transcriptome database and plasmid library enable the systematic and fast iPSC differentiation protocol development.

How it Works

STEP 1

Project Design Consultation

Whether you’re an experienced stem cell researcher or just getting started, our scientists are here to answer your questions and provide ongoing support. All stem cell services begin with a free consultation to define the scope of the project, including the desired differentiated cell type, the production scale (1-50 million viable cells), and desired characterization assays (ICC, MEA, etc.).

If you don’t currently have an iPSC line, we can also provide assistance in obtaining iPSC lines from iPSC banks or gene-editing service providers. Consultations are free, so request a consultation today to discuss your project requirements. iPSC lines Elixirgen recognize are listed here.

STEP 2

Stem Cell Expansion or Adaptation (Optional)

Upon receiving your frozen or live stem cell line(s), we expand or adapt the cells in optimal conditions for growth and differentiation. For our transcription factor-based differentiation platform, we use feeder-free, single-cell passaging conditions for iPSC expansion/adaptation for best results.

During iPSC expansion, we produce working and back-up stocks of the iPSC line along with a certificate of analysis to verify pluripotency and karyotype upon request.

STEP 3

Stem Cell Differentiation

Our proprietary stem cell differentiation technology produces functional, highly pure populations neurons in as little as 1 week without leaving a genetic footprint.

Our standard differentiated cell types include a variety of neuronal subtypes (GABAergic, dopaminergic, cholinergic, or sensory) and astrocytes but we can also use our stem cell expertise to develop a custom differentiation strategy for generating your desired cell or tissue type.

STEP 4

Characterization

Prior to shipping, we conduct a variety of quality control checks to ensure that differentiated cells are free from contaminants, express lineage-specific markers, and have optimal post-thaw viability.

We also offer a variety of optional in-house assay services, including microelectrode array (MEA), neurite outgrowth assay, and calcium transient assay, if in depth functional characterization is desired.

Differentiated cells are shipped either live or cryopreserved depending on preference and are supplied with media supplements and detailed instructions for optimal cell maintenance.

Tetsuya Tanaka, Ph.D.

Director, Molecular Biology

Talk to an Expert

Our stem cell services start from just $1,000. Project design consultations are free, so contact us today to find out how we can help you accelerate your research.

Frequently Asked Questions

How much do the stem cell services cost?

The price for the differentiation of one hPSC (iPS or ES) line starts at just $1,000.

I don't have my own cells, where can I order an iPSC line?

If you do not already have an established iPSC line, you can find patient iPSC lines in your interest here. Contact us for you to learn more about sourcing iPSC lines and differentiation.

How do I ship my hPSC line?

Sending biomaterials is always challenging. However, Elixirgen Scientific has a lot of experience in cross border logistics for cells and biological materials. Our knowledge and expertise will navigate you to properly prepare your iPSCs to ship. We use dry ice shipment in the US and liquid nitrogen dry shipper internationally to ship cryopreserved cells. We can also accept live hPSC lines to speed up an entire process and lower total fees.

Can you reprogram my cells into iPSCs?

We do not currently offer services for reprogramming cells into iPSCs. However, we can work with our partners to take care of this reprogramming services from fibroblast or PBMC.

List of diseases and mutations

DiseaseMutant genes (# of iPSC lines)Number of total patient iPSC lines
ABCA1 heterozygousABC1 (2)2
AbetalipoproteinemiaMTP (2)2
Acromesomelic dysplasiaNPR2 (1)1
Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD)1
Adrenoleukodystrophy (ALD)1
Adult-onset Still’s disease (AOSD)1
Age-related macular degeneration (AMD)121
Aicardi syndrome1
Alexander diseaseGFAP (3)6
Allergic granulomatous angiitis1
Alzheimer's disease (AD)APOE (10), APOE4 (3), APP (4), C9ORF (1), CD33 (2), MAPT (2), PSEN1 (14), PSEN2 (1), TBK1 (1), TREM2 (3)180
Alzheimer's disease (AD) (Gene-edited)APP (6), PSEN1 (8)14
Alzheimer's disease (AD) (familial)APP (3), APPV7171 (4), PSEN1 (1), PSEN2 (1)11
Amyotrophic lateral sclerosis (ALS)ASYMPTOMATIC C9ORF72 CARRIER (1), C9ORF72 (46), FIG4 (1), FUS (3), SETX (1), SETX, SOD1 (1), SOD1 (36), SOD1 > D90A (1), TARDBP (5), VCP (1)532
Anemia (phenotype)1
Angelman syndromeUBE3A (2)10
Aplastic anemia3
Arrhythmogenic right ventricular cardiomyopathy2
Arteriolosclerosis2
Associated pulmonary arterial hypertension18
Ataxia-telangiectasia3
Atrial fibrillation14
Atrial tachycardia1
Autism spectrum disorder (ASD)110
Autoimmune hemolytic anemia (AHA) / Idiopathic warm (AHA)1
Bardet-biedl syndrome22
Batten disease (cln3)CLN3 (23)23
Batten disease (cln6)8
Behçet’s disease2
Beta thalassemiaHBB (2)2
Bethlem myopathy2
Bilateral frontoparietal polymicrogyriaGPR56 (1)1
Bipolar disorder30
Blinding eye disease18
Borderline NASH (fatty liver disease)2
Breast cancerBRCA1 (3)3
Brugada syndrome6
Buerger’s disease1
Cardiomyopathy48
Carpal tunnel syndrome18
Catecholaminergic polymorphic ventricular tachycardiaRYR2 (2)2
Ccanavan DiseaseASPA (1)1
Cchoroideremia (CHM)CHM (1), NGLY1 (1)4
Cerebral creatine deficiency syndrome 1 (CCDS1)SLC6A8 (1)1
Cerebral palsy (CP)19
Cerebrovascular disease4
Ceroid lipofuscinosisCHM (1), CLN2 (1)2
Charcot-Marie-Tooth diseaseFIG4 (1), MFN2 (10), MPZ (2), PMP22 (7), VCP (1)22
Chromosome 16p11.2 deletion syndrome5
Chronic inflammatory demyelinating polyneuropathy (CIDP)2
Chronic myeloid leukemia1
Congenital disorder of deglycosylation (CDDG)CFTR (1)1
Congenital heart block2
Congenital ichthyosis / Ichthyosis syndrome1
Congenital insensitivity to pain with anhidrosis (CIPA)2
Congenital myasthenic syndromeGFPT1 (1)7
Congenital myopathyMTM11 (1)1
ControlC9ORF72 (5), CCR5 (1), GFAP CORRECTED (2), HBB (1), HD (5), HNF1A (1), MECP2 (2), NGN2 (2), SNCA (1), SOD1 > D90A CORRECTED (1), TAF1 VARIANT CORRECTED (4)25
Coronary artery disease43
Corticobasal degeneration (CBD)1
Crohn's disease3
Crow‐Fukase syndrome2
Cystic Fibrosis (CF)DMPK (1)1
Cystinosis1
DMDDMD (5)5
DMRV / GNE myopathy2
Danon disease1
Definite NASH (fatty liver disease)32
DiabetesHNF1A (2)3
Diabetes mellitus60
Diabetes mellitus type II12
Diabetes type I21
Diabetes type II95
Diabetes type unknown4
Diabetic retinopathy (DR)32
Diamond-Blackfan anemia1
Dilated cardiomyopathy (DCM)303
Distal Myopathy3
Down syndrome47,XX,+21 (4), 47,XY,+21 (3)8
Dravet syndromeSCN1A (11)11
Drug-induced liver injury (DILI)4
Duchenne Muscular dystrophy (DMD)DMD (1)2
Dystrophia myotonica 1 (DM1)DMPK (1)1
Ehlers-Danlos syndromeCOL3A1 (1)2
Eosinophilic granulomatosis with polyangiitis (EGPA)1
Eosinophilic sinusitis1
Epidermolysis bullosa1
EpilepsyALG13 (1), GABRA1 (1), KCNC1 (1), PCDH19 (2), SCN2A (1)57
Fabry disease3
Facioscapulohumeral muscular dystrophy 1 (FSHD1)LRIF1 (1)6
Familial Mediterranean fever1
Fatty liver disease - steatosis (not NASH)2
Focal cortical dysplasia (FCD)2
Focal segmental glomerulosclerosis20
Fragile X syndromeFMR1 (4)4
Friedreich ataxia 1 (FRDA)FXN (2)2
Frontotemporal degenerationC9ORF72 (4), GRN (4), MAPT (10), PGRN (2), VCP (1)25
Frontotemporal dementia (FTD)C9ORF72 (6), MAPT (15)30
Frontotemporal lobar degeneration (FTLD)2
GM1-gangliosidosis1
Galactosialidosis1
Gaucher diseaseGBA (1)2
Giant cell arteritis (GCA)2
Glaucoma20
Glut1 deficiency syndrome 1 (Glut1DS1)SLC2A1 (1)1
Glycogen storage disease / GSD type V (muscle glycogen phosphorylase deficiency)1
Glycosylphosphatidylinositol(GPI) anchor deficiency3
Granulomatosis with polyangiitis (GPA)1
Hemiconvulsion-hemiplegia-epilepsy syndrome2
Hemimegalencephaly1
Hepatitis C (HCV)91
Hereditary dystonia1
Homozygous familial hypercholesterolemiaLDLR (6)6
Hunter syndrome2
Huntington's disease (HD)HD (14), HTT (36), IT15 (1), SMN1 (1)58
Hurler syndromeIDUA (1)1
Hutchinson-gilford progeria syndrome (HGPS)2
HyperalphalipoproteinemiaSR-BI (2)2
Hypertrophic cardiomyopathyTNNT2 (1)83
Idiopathic aplastic anemia1
Idiopathic pulmonary arterial hypertension16
Idiopathic pulmonary fibrosis (IPF)182
Idiopathic thrombocytopenic purpura1
IgG4-related disease1
IgG4-related thyroid disease1
Inappropriate sinus tachycardia1
Infantile neuroaxonal dystrophy (INAD)PLA2G6 (5)5
Intellectual disability (ID)60
Interstitial lung disease1
Isaacs syndrome1
Isogenic control3
Kearns-sayre syndrome (KSS)1
Keratoconus2
Krabbe diseaseGALC (1)1
Landau-Kleffner syndrome1
Left ventricular hypertrophy15
Left ventricular non-compaction cardiomyopathy10
Lennox-Gastaut syndrome (LGS)2
Lesch-nyhan syndrome (LNS)HPRT1 (1)1
Lewy body dementia8
Lewy body dementia (LBD)1
Limb-girdle muscular dystrophyDYSF (5)5
Limb-girdle muscular dystrophy (LGMD2b)DYSF (15)15
LissencephalyDCX (1)1
Long QT syndrome3
Long QT syndrome (familial)13
Long QT syndrome 1 (LQT1)3
Long QT syndrome 2 (LQT2)KCNH2 (1)1
Long QT syndrome 3 (LQT3)SCN5A (1)1
MELAS1
Malignant rheumatoid arthritis (MRA)1
Mental illnessDISC1 EXON 8 WILD-TYPE (2)2
Mental retardationCHAMP1 (2), SYNGAP1 (1)3
Mesial temporal lobe epilepsy with hippocampal sclerosis2
Microscopic polyangiitis (MPA)1
Migraine disorderMAJOR CHR17 AMPLIFCATION; MINOR CHR7 DELETION (1)28
Mild left ventricular hypertrophy1
Miller-dieker lissencephaly syndrome (MDLS)1
Mitochondrial diseases1
Mixed Connective-Tissue Disease (MCTD)1
Monogenic diabetes13
Mortor dominant1
Moyamoya disease3
Mucopolysaccharidosis (MPS)SGSH (1)3
Multifocal motor neuropathy (MMN)1
Multiple sclerosis (MS)4
Multiple system atrophy (MSA)6
Muro disease (Kii ALS/PDC)3
Muscular dystrophyDMD (5), LAMA2 (1), POMT2 (1)9
Myasthenia Gravis (MG)1
Myocardial infarction18
Myoclonic epilepsyCHD2 (1)1
Myotonic dystrophyCNBP (4), DMPK (1)9
Nescav syndromeKIF1A (5)6
Neurodegeneration with brain iron accumulation 5 (NBIA5)WDR45 (1)1
Neurodevelopmental disorderDHPS (1)1
Neuroferritinopathy1
Neurofibromatosis type1 (NF1)1
Neurofibromatosis type2 (NF2)1
Neuromyelitis Optica4
Neuromyelitis Optica Spectrum Disorders (NMOSD)1
Neuronal migration disorderPIK3R2 (1)3
NeuropathyGARS (2), SCN9A (6)39
Niemann-pick diseaseNPC1 (1), SMPD1 (3)5
Non-als motor neurone disease1
Ohtahara syndromeSTXBP1 (1)1
Ornithine transcarbamylase deficiency (OTCD)1
Osteogenesis imperfecta type iv (OI4)COL1A2 (1)1
PACS1 (Schuurs-Hoeijmakers) syndromePACS1 (2)2
Pain agnosiaSCN11A (2)2
ParkinsonismGBA (2), LRRK2 (6), MAPT (1), PARK2 (4), PINK1 (1), SNCA (3)26
Parkinson’s disease (PD)GBA (18), LRRK2 (8), SNCA (9)99
Paroxysmal nocturnal hemoglobinuria (PNH)1
Pemphigoid (including epidermolysis bullosa acquisita)2
Pemphigus2
Periodic paralysis1
PhenylketonuriaPAH PAH (1)2
Pick's disease1
Pitt-hopkins syndrome (PTHS)TCF4 (1)1
Polyarteritis nodosa (PAN)2
Polymicrogyria1
Pompe’s disease (adult type)1
Primary antiphospholipid syndrome2
Primary erythromelalgiaSCN9A (2)4
Primary immunodeficiency syndrome3
Primary lateral sclerosis (PLS)7
Primary open angle (POAG)20
Primary progressive aphasia (PPA)1
Progressive multifocal leukoencephalopathy (PML)1
Progressive supranuclea palsy (PSP)1
Prolonged QT interval6
Pulmonary arterial hypertension ALK1 (2), BMPR2 (4)6
Pulmonary atresia1
Pustular psoriasis1
Pyogenic sterile arthritis / Pyoderma gangrenosum and acne syndrome1
Rasmussen encephalitis2
Relapsing polychondritis (RP)1
Resolved systolic anterior motion1
Restrictive cardiomyopathy1
Retinitis pigmentosa5
Rett syndromeFOXG1 (5), MECP2 (6), SHANK3 (1)15
Right ventricular outflow tract premature ventricular contractions2
Ring chromosome 20 syndrome2
Sanfilippo syndrome / MPS IIIC (acetyl-CoA:heparan-α-D-glucosaminide N-acetyltransferase deficiency)1
Schizophrenia4
Semantic Dementia2
Severe combined immunodeficiencyADA (2)2
Sickle cell anemiaHBB (55)55
Sjögren’s syndrome1
Skeletal displasia4
Small atrial septal defect1
Smith-magenis syndrome (SMS)1
Spinal muscular atrophySMN1 (14)18
Spinal-Bulbar Muscular Atrophy (SBMA)10
Spinocerebellar Degeneration14
Spinocerebellar ataxia type 12
Spinocerebellar ataxia type 3ATXN3 (4)4
Spondylometaphyseal displasia2
Stevens-Johnson syndrome (SJS)1
Sturge-Weber syndrome1
Subacute sclerosing panencephalitis (SSPE)2
Syringomyelia1
Systemic amyloidosis2
TNF receptor-associated periodic syndrome1
Takayasu arteritis3
Tangier diseaseABC1 (2), ABCA1 (4)6
Tay-sachs disease (TSD)HEXA (1)1
Thrombotic thrombocytopenic purpura (TTP)1
Tricuspid atresia1
Tuberous sclerosisTSC2 (2)3
Ventricular tachycardia5
Vertebrobasilar insufficiency(VBI)1
Vici syndrome (VICIS)EPG5 (1)1
Werner syndrome1
West syndrome1
Wilson’s disease4
Wolfram syndrome1
Wolman disease1
X-linked creatine transporter deficiency1
X-linked dystonia ParkinsonismTAF1 VARIANT (34)34
Xeroderma pigmentosum2