Cholinergic Neurons

Gain a deeper understanding of the complexities of neuronal signaling and tease apart variations due to age, gender, and donor variability with neurons derived from human iPS cells. Our Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons give you access to the same cells with every order for more biologically relevant and reproducible studies.

iPSC-derived Cholinergic Neurons from Healthy and Affected Donors

Elixirgen Scientific’s Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons are created using human iPS cells made available through a license from The California Institute for Regenerative Medicine (CIRM).

The CIRM iPS cell repository includes over 1,500 iPS cell lines, so please contact us if you would like cholinergic neurons derived from a specific donor cell line. Every lot of iPSCs is differentiated into cholinergic neurons using our proprietary transcription factor-based technology that is “footprint-free” and delivers functional, high-quality cells.

Advantages

  • Functionally validated
  • Highly pure population
  • No genetic footprint
  • Multiple donors and disease types available

Cat No. Product Name Disease StatusDescription
CH-SeV-CW50065 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (F, 74 yr donor) - Healthy Control Healthy Control Cryopreserved human iPSC-derived cholinergic neurons from healthy control (F, 74)
CH-SeV-CW70067 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (F, 21 yr donor) - Healthy Control Healthy Control Cryopreserved human iPSC-derived cholinergic neurons from healthy control (F, 21)
CH-SeV-CW50023 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (M, 69 yr donor) - Healthy Control Healthy Control Cryopreserved human iPSC-derived cholinergic neurons from healthy control (M, 69)
CH-SeV-CW10149 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (M, 38 yr donor) - Healthy Control Healthy Control Cryopreserved human iPSC-derived cholinergic neurons from healthy control (M, 38)
CH-SeV-CW20300 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (M, 10 yr donor) - Healthy Control Healthy Control Cryopreserved human iPSC-derived cholinergic neurons from healthy control (M, 10)
CH-SeV-CW50025 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (F, 68 yr donor) - Alzheimer's Disease Alzheimer's Disease Cryopreserved human iPSC-derived cholinergic neurons from Alzheimer's Disease patient (F, 68)
CH-SeV-CW50113 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (M, 68 yr donor) - Alzheimer's Disease Alzheimer's Disease Cryopreserved human iPSC-derived cholinergic neurons from Alzheimer's Disease patient (M, 68)
CH-SeV-CW50114 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (F, 72 yr donor) - Alzheimer's Disease Alzheimer's Disease Cryopreserved human iPSC-derived cholinergic neurons from Alzheimer's Disease patient (F, 72)
CH-SeV-CW50115 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (F, 67 yr donor) - Alzheimer's Disease Alzheimer's Disease Cryopreserved human iPSC-derived cholinergic neurons from Alzheimer's Disease patient (F, 67)
CH-SeV-CW50137 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (F, 70 yr donor) - Alzheimer's Disease Alzheimer's Disease Cryopreserved human iPSC-derived cholinergic neurons from Alzheimer's Disease patient (F, 70)
CH-SeV-CW50147 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (M, 71 yr donor) - Alzheimer's Disease Alzheimer's Disease Cryopreserved human iPSC-derived cholinergic neurons from Alzheimer's Disease patient (M, 71)
CH-SeV-CW50104 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (M, 79 yr donor) - Alzheimer's Disease Alzheimer's Disease Cryopreserved human iPSC-derived cholinergic neurons from Alzheimer's Disease patient (M, 79)
CH-SeV-CW50107 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (M, 72 yr donor) - Alzheimer's Disease Alzheimer's Disease Cryopreserved human iPSC-derived cholinergic neurons from Alzheimer's Disease patient (M, 72)
CH-SeV-CW50169 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (F, 68 yr donor) - Alzheimer's Disease Alzheimer's Disease Cryopreserved human iPSC-derived cholinergic neurons from Alzheimer's Disease patient (F, 68)
CH-SeV-CW50170 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (F, 64 yr donor) - Alzheimer's Disease Alzheimer's Disease Cryopreserved human iPSC-derived cholinergic neurons from Alzheimer's Disease patient (F, 64)
CH-SeV-CW50173 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (F, 74 yr donor) - Alzheimer's Disease Alzheimer's Disease Cryopreserved human iPSC-derived cholinergic neurons from Alzheimer's Disease patient (F, 74)
CH-SeV-CW50174 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (F, 76 yr donor) - Alzheimer's Disease Alzheimer's Disease Cryopreserved human iPSC-derived cholinergic neurons from Alzheimer's Disease patient (F, 76)
CH-SeV-CW50175 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (F, 77 yr donor) - Alzheimer's Disease Alzheimer's Disease Cryopreserved human iPSC-derived cholinergic neurons from Alzheimer's Disease patient (F, 77)
CH-SeV-CW50176 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (M, 74 yr donor) - Alzheimer's Disease Alzheimer's Disease Cryopreserved human iPSC-derived cholinergic neurons from Alzheimer's Disease patient (M, 74)
CH-SeV-CW50177 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (F, 85 yr donor) - Alzheimer's Disease Alzheimer's Disease Cryopreserved human iPSC-derived cholinergic neurons from Alzheimer's Disease patient (F, 85)
CH-SeV-CW60130 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (F, 6 yr donor) - Epilepsy Epilepsy Cryopreserved human iPSC-derived cholinergic neurons from Epilepsy patient (F, 6)
CH-SeV-CW60231 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (M, 6 yr donor) - Epilepsy Epilepsy Cryopreserved human iPSC-derived cholinergic neurons from Epilepsy patient (M, 6)
CH-SeV-CW60236 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (F, 11 yr donor) - Epilepsy Epilepsy Cryopreserved human iPSC-derived cholinergic neurons from Epilepsy patient (F, 11)
CH-SeV-CW20026 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (M, 10 yr donor) - Autism Spectrum Disorder Autism Spectrum Disorder Cryopreserved human iPSC-derived cholinergic neurons from Autism Spectrum Disorder patient (M, 10)
CH-SeV-CW20090 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (F, 18 yr donor) - Autism Spectrum Disorder Autism Spectrum Disorder Cryopreserved human iPSC-derived cholinergic neurons from Autism Spectrum Disorder patient (F, 18)
CH-SeV-CW10130 Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons (M, 36 yr donor) - Fatty Liver Disease Fatty Liver Disease Cryopreserved human iPSC-derived cholinergic neurons from Fatty Liver Disease patient (M, 36)

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Our Quick-Neuron™ Cholinergic - SeV and mRNA Kits (small and large sizes available) allow researchers to quickly, easily, and efficiently differentiate their iPS or ES cell line of choice into cholinergic neurons. The kits utilize temperature sensitive Sendai virus or synthetic mRNAs to deliver our proprietary cocktail of transcription factors that induce differentiation without leaving a genetic footprint.

Cat No. Product Name Disease StatusDescription
CH-SeV Quick-Neuron™ Cholinergic - SeV Kit This kit differentiates human pluripotent stem cells into cholinergic neurons in 6 days using Sendai virus.
CH-mRNA Quick-Neuron™ Cholinergic - mRNA Kit This kit differentiates human pluripotent stem cells into cholinergic neurons in 7 days using synthetic mRNA.
CH-MM Quick-Neuron™ Cholinergic - Maintenance Medium Medium for long-term maintenance of human iPS/ESC-derived cholinergic neurons.

Characterization

Maintenance of iPSC-derived cholinergic neurons. Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons on Days 1-3 post-thaw (scale bar = 100 μm).

iPSC-derived cholinergic neurons express neuronal markers and display typical neurite growth. Immunofluorescent staining of Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons on Day 3 post-thaw that shows expression of the pan-neuronal marker TUBB3 and the cholinergic neuron marker ChAT (scale bar = 100 μm).

Frequently Asked Questions

Do I need a license to commercialize products using Elixirgen’s iPSC-derived neurons?

No. The use of differentiated cells provided by Elixirgen Scientific does not require any additional license from other parties for any type of use, except for use in humans or for therapeutic or diagnostic use.

What sizes of Quick-Neuron™ Cholinergic - Human iPSC-derived Neurons are available?

Off the shelf, we offer small (>1 million viable cryopreserved cells) and large (5x >1 million viable cryopreserved cells) sizes. If you are looking for a larger quantity, please contact us for pricing information.